Publications
 
   
Sato K., Ernstrom G.G., Watanabe S., Weimer R.M., Chen C.H., Sato M., Siddiqui A., Jorgensen E.M., Grant B.D. 2009. Differential requirements for clathrin in receptor-mediated endocytosis and maintenance of synaptic vesicle pools. Proc Natl Acad Sci USA 106:1139-1144.. PDF
Gu, M., K. Schuske, S.i Watanabe, Q. Liu, P. Baum, G. Garriga, and E.M. Jorgensen. 2008. mu2 adaptin facilitates but is not essential for synaptic vesicle recycling in Caenorhabditis elegans. J. Cell Biol. 183, 881-892. PDF

Frøkjær-Jensen, C., M.W. Davis, C.E. Hopkins, B. Newmann, J.M. Thummel, S-P. Olesen, M. Grunnet and E.M. Jorgensen. 2008. Single copy insertion of transgenes in C. elegans. Nature Genetics 40, 1375-1383.

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Hammarlund, M., P. Nix, L. Hauth, E.M. Jorgensen, and M..J. Bastiani. 2009. Axon regeneration requires a conserved MAP kinase pathway. Science 323, 802-806. PDF

Palfreyman, M., and E.M. Jorgensen. 2009. In vivo analysis of membrane fusion. In Encyclopedia of Life Sciences, John Wiley & Sons. Chichester http://www.els.net/ [DOI: 10.1002/ 9780470015902.a0020891]. Review.

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Palfreyman, M., and E.M. Jorgensen. 2008. Roles of SNARE proteins in synaptic vesicle fusion. In Molecular Mechanisms of Neurotransmitter Release, Humana Press, p35-59. Review PDF
Davis, M.W., J. Morton, D. Carroll and E.M. Jorgensen. 2008. Gene activation using FLP recombinase in C. elegans. PLoS Genetics 4(3) e1000028. PDF
Robert, V.J., M.W. Davis, E.M. Jorgensen and J-L Bessereau. Gene conversion and end-joining repair double-strand breaks in the C. elegans germline. Genetics 180, 673 - 679. PDF
Hammarlund, M., S. Watanabe, K. Schuske, and E.M. Jorgensen. 2008. CAPS and syntaxin dock dense core vesicles to the plasma membrane in neurons. Journal of Cell Biology 180 483-491. PDF

Pan, C.L, P. Baum, M. Gu, E. M. Jorgensen, S. Clark, and G. Garriga. 2008. C. elegans AP-2 and retromer control Wnt secretion by regulating MIG-14/Wntless.  Developmental Cell 14, 132-139.

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Jung, N.,  M. Wienisch, M. Gu, J.B. Rand, S. L Müller, G. Krause, E. M. Jorgensen, J. Klingauf, V. Haucke. 2007. Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2. Journal of Cell Biology 179, 1497-1510.

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Beg, A., P., G. Ernstrom, P. Nix, M.W. Davis and E.M. Jorgensen. 2008. Protons act as a transmitter for muscle contraction in C. elegans. Cell 132: 149-160.

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Williams, S.L., S. Lutz, N.K. Charlie, C. Vettel, M. Ailion, C.Coco, J.J.G. Tesmer, E.M. Jorgensen, T. Wieland, and K.G. Miller.  2007.  Trio's Rho-specific GEF domain is the missing Gq effector in C. elegans. Genes and Development 21, 2731-2746.

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White, J.Q., T.J. Nicholas, J. Gritton, L. Truong, E.R. Davidson and E.M. Jorgensen. 2007. The sensory circuitry for sexual attraction in C. elegans males. Current Biology 17, 1847-1857.

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Peters, M. T. Teramoto, J.Q. White, K. Iwasaki and E. M. Jorgensen. A calcium wave mediated by gap junctions coordinates a rhythmic behavior in C. elegans.  2007. Current Biology 17, 1601-1608.

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Jospin, M., S. Watanabe, D. Joshi, S. Young, K. Hamming, C. Thacker, T. Snutch, E.M. Jorgensen and K. Schuske. 2007. UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants. Current Biology 17, 1595-1600.

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Hammarlund, M., M. Palfreyman, S. Watanabe, S. Olsen, and E.M. Jorgensen. 2007. Open syntaxin docks synaptic vesicles. PLoS Biology 5 (8): e198, 1695-1711.

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Schuske, K. M.T. Palfreyman, S. Watanabe, and E. M. Jorgensen. 2007. UNC-46, a novel protein required for trafficking of the vesicular GABA transporter. Nature Neuroscience 10, 846-853.

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Palfreyman, M., and E.M. Jorgensen. 2007. PKC defends crown against Munc13. Neuron 54, 179-180. Review.

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Speese, S., M. Petrie, K. Schuske, M. Ailion, K. Ann, K. Iwasaki, E.M. Jorgensen, and T.F.J. Martin. 2007. UNC-31 (CAPS) Is Required for Dense-Core Vesicle But Not Synaptic Vesicle Exocytosis in Caenorhabditis elegans. Journal of Neuroscience 27, 6150-6162.

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Bednarek, E., L. Schaheen, J. Gaubatz, E.M. Jorgensen and H. Fares. 2007. The plasma membrane calcium-ATPase is required for clathrin-mediated endocytosis. Traffic 8, 543-553.

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Hammarlund, M., E.M. Jorgensen, M.J. Bastiani. 2007. Axons break in animals lacking beta-spectrin. J Cell Biol. 176, 269-275.

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Morton, J., M.W. Davis, E.M. Jorgensen, and D. Carroll. 2006. Induction and repair of zinc-finger nuclease-targeted double-strand breaks in C. elegans somatic cells. Proc Natl Acad Sci USA 103, 16370-16375.

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Abraham, C., H. Hutter, M.T. Palfreyman, G. Spatkowski, R. Weimer, R. Windoffer, E.M. Jorgensen and R. Leube. 2006. Synaptic tetraspan vesicle membrane proteins are conserved but not needed for synaptogenesis and neuronal function in C. elegans. Proc Natl Acad Sci USA 103, 8227-8232.

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Wardell, B., P.S. Marik, D. Piper, T. Rutar, E.M. Jorgensen and B.A. Bamber. 2006.  Residues in the first transmembrane domain of the Caenorhabditis elegans GABAA receptor confer sensitivity to the neurosteroid pregnenolone sulfate.  Brit. J. Pharm.  148, 162-172.

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Davis*, M.W., M. Hammarlund*, T. Harrach, S. Olsen, and E.M. Jorgensen. 2005. Rapid single nucleotide polymorphism mapping in C. elegansBMC genomics 6, 118.

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Jorgensen, E.M.  2005.  GABA. WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.14.1, http://www.wormbook.org.  Book Chapter.

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Hammarlund, M.*, M.W. Davis*, H. Nguyen, D. Dayton, and E.M. Jorgensen. 2005. Heterozygous insertions alter crossover distribution but allow crossover interference in C. elegansGenetics, 171: 1047-1056.
• Commentary: Hawley, R. S. (2005). Faculty of 1000.

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Williams, D.C., T. Boulin, A.F. Ruaud, E.M. Jorgensen, and J.L Bessereau. 2005. Characterization of Mos1-Mediated Mutagenesis in Caenorhabditis elegans: A Method for the Rapid Identification of Mutated Genes.  Genetics, 169: 1779-1785.

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Bamber, B.A., J.E. Richmond, J.F. Otto and E.M. Jorgensen. 2005.  The composition of the GABA receptor at the Caenorhabditis elegans neuromuscular junction.  Br. J. Pharm. 144, 502 - 509.

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Davis, M.W., A.J. Birnie, A.C. Chan, A.P. Page, and E.M. Jorgensen. 2004. A conserved metalloprotease mediates ecdysis in C. elegansDevelopment 131, 6001-6008.

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Jorgensen, E.M. 2004. Dopamine: should I stay or should I go now?  Nature Neuroscience 7, 1019-1021. Review.

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Schuske, K., and E.M. Jorgensen, 2004. The vesicular glutamate transporter: shooting blanks.  Science 304, 1750-1752. Review.

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Schuske, K., A. Beg, and E.M. Jorgensen, 2004. The GABA nervous system in Caenorhabditis elegansTrends in Neurosci. 27, p407-414. Review.

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Rostaing, P., R.M. Weimer, E.M. Jorgensen, A. Triller and J.L Bessereau. 2004. Preservation of immunoreactivity and fine structure of C. elegans tissues using high-pressure freezing.  J. Histochemistry and Cytochemistry 52: 1–12.

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Schuske, K.R., J.E. Richmond, D.S. Matthies, W.S. Davis, S. Runz, D.A. Rube, A.M. van der Bliek and E.M. Jorgensen. 2003. Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin.  Neuron 40, 749-762.
• Commentary: Endophilin and synaptojanin hook up to promote synaptic vesicle endocytosis.  Song and K. Zinsmaier.  2003.  Neuron 40, 665-670. (PDF*)

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Beg, A., and E.M. Jorgensen. 2003. An excitatory GABA receptor. Nature Neuroscience 6, 1145-1152.
• Commentary: Exciting guts with GABA.  Goaillard, J-M., and E. Marder.  2003. Nature Neuroscience 6, 1121-1122.

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Lesa, G., M. Palfreyman, D. H. Hall, M. T. Clandinin, C. Rudolph, E.M. Jorgensen and G. Schiavo. 2003. Long chain polyunsaturated fatty acids are required for efficient neurotransmission in C. elegansJ. Cell Science 116, 4965-4975.

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Weimer, R., J.E. Richmond, W.S. Davis, J. Gritton, G. Hadwiger, M. Nonet and E.M. Jorgensen. 2003. Defects in synaptic vesicle docking in unc-18 mutants. Nature Neuroscience 6, 1023-1030.

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Weimer, R., and E.M. Jorgensen. 2003. Controversies in synaptic vesicle exocytosis.  J. Cell Sci. 116, 3661-3666.   Review. 

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Bamber, B.A.; R.E. Twyman, and E.M. Jorgensen. 2003. Pharmacological characterization of the homomeric and heteromeric UNC-49 GABA receptors in C. elegans  British Journal Pharmacology, 138, 883-893.

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Corsi A.K. T.M., Brodigan, E.M. Jorgensen, M. Krause. 2002. Characterization of a dominant negative C. elegans Twist mutant protein with implications for human Saethre-Chotzen syndrome. Development 129: 2761-2772.

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Jorgensen, E.M., and S.E. Mango. 2002. The art and design of genetic screens: Caenorhabditis elegans. Nature Review Genetics 3, 356-369.

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Halevi, S., J. McKay, M. Palfreyman, L. Yassin, M. Eshel, E. Jorgensen, and M. Treinin. 2002. The C. elegans ric-3 gene is required for maturation of nicotinic acetylcholine receptors.  EMBO J. 21, 1012-1020.

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Knobel, K., W. Davis and E.M. Jorgensen, and M. Bastiani. 2001. UNC-119 suppresses axon branching in C. elegans Development  128: 4079-4092.

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Koushika, S., J. E. Richmond, G. Hadwiger, R. Weimer, E. M. Jorgensen and M. L. Nonet. 2001. A post-docking role for active zone protein Rim.  Nature Neuroscience 4, 997-1005.

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Bessereau, J.L., A. Wright, D.C. Williams, K. Schuske, M.W. Davis and E.M. Jorgensen.  2001. Mobilization of a Drosophila transposon in the Caenorhabditis elegans germ line. Nature 413, 70-74.

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Harris, T.W., K. Schuske, and E.M. Jorgensen. 2001. Synaptic vesicle endocytosis in C. elegans. Traffic 2, 597-605.  Review.

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Richmond, J.E., R.M. Weimer, and E.M. Jorgensen. 2001. An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming.  Nature 412, 338-341.

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Yook, K.J., S.R. Proulx and E.M. Jorgensen. 2001. Rules of nonallelic noncomplementation at the synapse in Caenorhabditis elegansGenetics 158, 209-220.

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Harris, T.W., E. Hartwieg, H.R. Horvitz, and E.M. Jorgensen. 2000. Mutations in synaptojanin disrupt vesicle recycling. J Cell Biol 150, 589-600.

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Hammarlund, M., W.S. Davis and E.M. Jorgensen. 2000. Mutations in b-spectrin disrupt axon outgrowth and sarcomere structure.  J. Cell Biol. 149, 931-942.
• Commentary: A protein accumulator.  Pinder, J.C. and A.J. Baines.  2003. Nature 406, 253-254. (PDF)*

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Richmond, J.E., W.S. Davis, and E.M. Jorgensen. 1999. UNC-13 is required for synaptic vesicle fusion in C. elegansNature Neuroscience 2, 959-964.

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Dal Santo, P., M.A. Logan, A.D. Chisholm and E.M. Jorgensen. 1999.The inositol trisphosphate receptor regulates a 50 second behavioral rhythm in C. elegansCell 98, 757-767.

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Knobel, K., E.M. Jorgensen and M. Bastiani. 1999. Growth cones stall and collapse during C. elegans development. Development 126, 4489-4498.

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Richmond, J.E., and E.M. Jorgensen. 1999. One GABA and two acetylcholine receptors function at the C. elegans neuromuscular junction. Nature Neuroscience 2, 791-797.

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Nonet, M., A.M. Holgado, F. Brewer, C.J. Serpe, B.A. Norbeck, J. Holleran, L. Wei, E. Hartweig, E.M. Jorgensen, and A. Alfonso. 1999. UNC-11, a Caenorhabditis elegans AP180 homologue, regulates the size and protein composition of synaptic vesicles. Mol. Biol. Cell 10, 2343-2360.

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Bamber, B., Beg, A., Twyman, R. and E.M. Jorgensen. 1999. The Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor  J. Neuroscience 19, 5348-5359.

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Jin, Y., Jorgensen, E., Hartwieg, E. and H.R. Horvitz. 1999. The C. elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development. J. Neuroscience 19, 539-548.

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Chalfie, M., Jorgensen, E.M.. 1998. C. elegans neuroscience: Genetics to genome. Trends Genet. 14:506-512.

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Gilbert, S.F., and E.M. Jorgensen. 1998. Wormwholes: a commentary on K.F. Schaffner's 'Genes, behavior and developmental emergentism'. Philosophy of Science 65, 259-266.

McIntire, S.L., R.J. Reimer, K. Schuske, R.H. Edwards and E.M. Jorgensen. 1997. Identification and characterization of the vesicular GABA transporter. Nature 389, 870-876.

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Nonet, M.L., J.E. Staunton, M. Kilgard, E. Hartwieg, T. Fergestad, H.R. Horvitz, E.M. Jorgensen, B.J. Meyer. 1997. C. elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles. J. Neurosci. 17: 8061-8073.

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Jorgensen, E.M., Hartwieg, E., Yook, K., and Horvitz, H.R. 1996. Genetic screens for synaptic function mutants in the nematode C. elegans.  In Basic Neuroscience in Invertebrates. Tenth Tokyo Metropolitan Institute for Neuroscience International Symposium. p. 217-226.

Jorgensen, E.M, E. Hartwieg, K. Schuske, M.L. Nonet, Y. Jin and H.R. Horvitz. 1995. Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans. Nature 378: 196-199.

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Jorgensen, E.M. and M. Nonet.  1995.  The C. elegans neuromuscular junction.  Seminars in Developmental Biology  6, 207-220.

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McIntire, S., E.M. Jorgensen, and H.R. Horvitz. 1993. Genes required for GABA function in the nematode Caenorhabditis elegans. Nature 364: 334-337.

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McIntire, S., E.M. Jorgensen, J. Kaplan and H.R. Horvitz. 1993. The GABAergic nervous system of Caenorhabditis elegans. Nature 364: 337-341.

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Riley, G.R., E.M. Jorgensen, R.K. Baker, and R. Garber. 1991. Positive and negative control of the Antennapedia promoter P2.  Development Sup. 1: 177-185.

Jorgensen, E.M., and R. Garber. 1987. Function and misfunction of the two promoters of the Antennapedia gene in Drosophila. Genes and Development 1: 544-555.

Stroeher, V., E.M. Jorgensen, and R. Garber. 1986. Multiple transcripts from the Antennapedia gene of Drosophila melanogaster. Mol. Cell. Biol. 6: 4667-4675.

Book Chapters

Yook, K. and E.M. Jorgensen. 2000. Genetics of the Caenorhabditis elegans nervous system.  In Encyclopedia of Genetics.  Ed. S. Brenner, J. Miller, Academic Press, New York. pp. 1309-1314.

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Jorgensen, E.M., and C. Rankin. 1997. Neural Plasticity.  In:C. elegans II.  Ed. D. Riddle, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.  pp. 769-790.