J. Michael McIntosh's Publications

McIntosh, J.M., L.J. Cruz, M.W. Hunkapillar, W.R. Gray and B.M. Olivera (1982) Isolation and structure of a peptide toxin from the marine snail Conus magus. Arch. Biochem. Biophys. 218:329-334. Gray, W.R., F.A. Luque, R. Gaylean, E. Atherton, R.C. Sheppard, B.L. Stone, A. Reyes, J. Alford, J.M. McIntosh, B.M. Olivera, L.J. Cruz and J. Rivier (1984) Conotoxin GI: Disulfide bridges, synthesis and preparation of iodinated derivatives. Biochemistry 23:2796-2802. Olivera, B.M., J.M. McIntosh, L.J. Cruz, F.A. Luque and W.R. Gray (1984) Purification and sequence of a presynaptic peptide toxin from Conus geographus venom. Biochemistry 23:5087-5090. McIntosh, J.M., B.M. Olivera, L.J. Cruz and W.R. Gray (1984) Gamma carboxyglutamate in a neuroactive toxin. J. Biol. Chem. 259:14343-14346. Olivera, B.M., J.M. McIntosh, C. Clark, D. Middlemas, W.R. Gray and L.J. Cruz (1985) A sleep-inducing peptide from Conus geographus venom. Toxicon 23:277- 282. Olivera, B.M., W.R. Gray, R. Zeikus, J.M. McIntosh, J. Varga, J. Rivier, V. de Santos and L.J. Cruz (1985) Peptide neurotoxins from fish-hunting cone snails. Science 230:1338-1343. Rivier, J., R. Galyean, W.R. Gray, A. Azimi-Zonooz, J.M. McIntosh, L.J. Cruz and B.M. Olivera (1987) Neuronal calcium channel inhibitors, synthesis of omega- conotoxin GVIA and effects on calcium uptake by synaptosomes. J. Biol. Chem. 262:1194-1198. Olivera, B.M., L.J. Cruz, V. de Santos, G.W. LeCheminant, D.Griffin, R. Zeikus, J.M. McIntosh, R. Galyean, J. Varga, W.R. Gray and J. Rivier (1987) Neuronal calcium channel antagonists discriminate between calcium channel subtypes using omega-conotoxin from Conus magus venom. Biochemistry 26:2086-2090. Myers, R.A., J.M. McIntosh, J. Imperial, R.W. Williams, T. Oas, J.A. Haack, J.F. Hernandez, J. Rivier, L.J. Cruz and B.M. Olivera (1990) Peptides from Conus venoms which affect Ca++ entry into neurons. J. Toxicol.-Toxin Rev. 9:179-202. Hillyard, D.R., V.D. Monje, I.M. Mintz, B.P. Bean, L. Nadasdi, J. Ramachandran, G. Miljanich, A. Azimi-Zonooz, J.M. McIntosh, L.J. Cruz, J.S. Imperial and B.M. Olivera (1992) A new Conus peptide ligand for mammalian presynaptic Ca2+ channels. Neuron 9:69-77. McIntosh, J.M., M.E. Adams, B.M. Olivera and F. Filloux (1992) Autoradiographic localization of the binding of calcium channel antagonist, [125I]w-Aga-IIIA, in rat brain. Brain Res. 594:109-114. Albensi, B.C., K.T. Ryujin, J.M. McIntosh, B.M. Olivera and F.M. Filloux (1993) Autoradiographic localization of [125I]w-conotoxin GVIA binding sites in human hippocampus and cerebellum. NeuroReport 4:1331-1334. McIntosh, J.M., T.A. Foderaro, W. Li, C.M. Ireland and B.M. Olivera (1993) Presence of serotonin in the venom of Conus imperialis. Toxicon 32:1561-1566. Filloux, F., A. Schapper, S. Naisbitt, B.M. Olivera and J.M. McIntosh (1994) Complex patterns of [125I]w-conotoxin GVIA binding site expression during postnatal rat brain development. Dev. Brain Res. 78:131-136. Nielsen, D., J. Dykert, J. Rivier and J.M. McIntosh (1994) Isolation of Lys-conopressin-G from the venom of the worm-hunting snail, Conus imperialis. Toxicon 32:845-848. McIntosh, J.M., D. Yoshikami, E. Mahe, D.B. Nielsen, J.E. Rivier, W.R. Gray and B.M. Olivera (1994) A nicotinic acetylcholine receptor ligand of unique specificity, α-conotoxin ImI. J. Biol. Chem. 269:16733- 16739. Johnson, D.S., Martinez, J., A.B. Elgoyhen, S.F. Heinemann and J.M. McIntosh (1995) α-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric α7 and α9 receptors. Molec. Pharmacol. 48:194- 199. Martinez, J.S., B.M. Olivera, W.R. Gray, A.G. Craig, D.R. Groebe, S.N. Abramson and J.M. McIntosh (1995) α- Conotoxin EI, a new nicotinic acetylcholine receptor antagonist with novel selectivity. Biochemistry 34:14519-14526. McIntosh, J.M., F. Ghomashchi, M.H. Gelb, D.J. Dooley, S.J. Stoehr, A.B. Giordani, S.R. Naisbitt and B.M. Olivera (1995) Conodipine-M, a novel phospholipase A2 isolated from the venom of the marine snail Conus magus. J. Biol. Chem. 270:3518-3526. McIntosh, J.M., A. Hasson, M.E. Spira, W.R. Gray, W. Li, M. Marsh, D.R. Hillyard, H. Terlau and B.M. Olivera (1995) A new family of conotoxins that block voltage-gated sodium channels. J. Biol. Chem. 270:16796-16802. Codignola, A., J.M. McIntosh, M.G. Cattaneo, L.M. Vicentini, F. Clementi and Emanuele Sher (1996) α- Conotoxin ImI inhibits nicotine-evoked hormone release and cell proliferation in human neuroendocrine carcinoma cells. Neurosci. Lett. 206:53-56. Cartier, G.E., D. Yoshikami, W.R. Gray, S. Luo, B.M. Olivera and J.M. McIntosh (1996) A new α-conotoxin which targets α3β2 nicotinic acetylcholine receptors. J. Biol. Chem. 271:7522-7528. Pereira, E.F.R., M. Alkondon, J.M. McIntosh and E.X. Albuquerque (1996) α-Conotoxin ImI: a competitive antagonist at α-bungarotoxin-sensitive neuronal nicotinic receptors in hippocampal neurons. J. Pharmacol. Exp. Thera. 278:1472-1483. Terlau, H., M. Stocker, K.-J. Shon, J.M. McIntosh and B.M. Olivera (1996) μO-Conotoxin MrVIA, a vertebrate sodium channel inhibitor which does not act through site I. J. Neurophys. 76:1423-1429. Craig, A.G., E.C. Jimenez, J. Dykert, D.B. Nielsen, J. Gulyas, F.C. Abogadie, J. Porter, J.E. Rivier, L.J. Cruz, B.M. Olivera and J.M. McIntosh (1997) A novel post-translational modification involving bromination of tryptophan: identification of the residue, L-6-bromotryptophan, in peptides from Conus imperialis and Conus radiatus venom. J. Biol. Chem. 272:4689-4698. Harvey, S.C., J.M. McIntosh, G.E. Cartier, F.N. Maddox and C.W. Luetje (1997) Determinants of specificity for α- conotoxin MII on α3β2 neuronal nicotinic receptors. Mol. Pharmacol. 51:336-342. Romano, S.J., P.C. Pugh, J.M. McIntosh and D.K. Berg (1997) Regulation of neuronal-type acetylcholine receptors containing the α7 gene product in vertebrate skeletal muscle. J. Neurobiol. 32:69-80. Tavazoie, S.F., M.F. Tavazoie, J.M. McIntosh, B.M. Olivera and D. Yoshikami (1997) Differential block of nicotinic synapses on B versus C neurones in symapthetic ganglia of frog by α-conotoxins MII and ImI. Brit. J. Pharmacol. 120:995-1000. Jacobsen, R., D. Yoshikami, M. Ellison, J. Martinez, W.R. Gray, G.E. Cartier, K. Shon, D.R. Groebe, S.N. Abramson, B.M. Olivera and J. M. McIntosh (1997) Differential targeting of nicotinic acetylcholine receptors by novel α- conotoxins. J. Biol. Chem. 272:22531-22537. Ullian, E.M., J.M. McIntosh and P.B. Sargent (1997) Rapid synaptic transmission in the avian ciliary ganglion is mediated by two distinct classes of nicotinic receptors. J. Neurosci. 17:7210-7219. Kulak, J.M., T.A. Nguyen, B.M. Olivera and J.M. McIntosh (1997) α-Conotoxin MII blocks nicotine-stimulated dopamine release in rat striatal synaptosomes. J. Neurosci. 17:5263-5270. Shon, K., S.C. Koerber, J.E. Rivier, B.M. Olivera and J. M. McIntosh (1997) Three-dimensional solution structure of α-Conotoxin MII, an α3β2 neuronal nicotinic acetylcholine receptor-targeted ligand. Biochemistry 36:15693-15700. Kehoe, J. and J.M. McIntosh (1998) Two distinct nicotinic receptors, one pharmacologically similar to the vertebrate α7-containing receptor, mediate CI currents in Aplysia neurons. J. Neurosci. 18:8198-8213. Luo, S., J.M. Kulak, G.E. Cartier, R.B. Jacobsen, D. Yoshikami, B.M. Olivera and J.M. McIntosh (1998) α- Conotoxin AuIB selectively blocks α3β4 nicotinic acetylcholine receptors and nicotine-evoked norepinephrine release. J. Neurosci. 18:8571-8579. Lopez, M.G., C. Montiel, C.J. Herrero, E. Garcia-Palomero, I. Mayorgas, J.M. Hernandez-Guijo, M. Villarroya, R. Olivares, L. Gandia, J.M. McIntosh, B.M. Olivera and A.G. Garcia (1998) Unmasking the functions of the chromaffin cell α7 nicotinic receptor by using short pulses of acetylcholine and selective blockers. Proc. Natl. Acad. Sci. USA 95:14184-14189. McIntosh, J.M., A.D. Santos and B.M. Olivera (1999) Conus peptides targeted to specific nicotinic acetylcholine receptor subtypes. Annu. Rev. Biochem. 68:59-88. Fu, Y., S.G. Matta, J.M. McIntosh and B.M. Sharp (1999) Inhibition of nicotine-induced hippocampal norepinephrine release in rats by α-conotoxins MII and AuIB microinjected into the locus coeruleus. Neurosci. Lett. 266:113-116. Quick, M.W., R.M. Ceballos, M. Kasten, J.M. McIntosh and R.A.J. Lester (1999) α3β4 Subunit-containing nicotinic receptors dominate function in rat medal habenula neruons. Neuropharmacology 38:769- 783. Jacobsen, R.B., R.G. DelaCruz, J.H. Grose, J.M. McIntosh, D. Yoshikami and B.M. Olivera (1999) Critical residues influence the affinity and selectivity of α-conotoxin MI for nicotinic acetylcholine receptors. Biochemistry 38:13310-13315. Luo, S., T.A. Nguyen, G.E. Cartier, B.M. Olivera, D. Yoshikami and J.M. McIntosh (1999) Single-residue alteration in α-conotoxin PnIA switches its nAChR subtype selectivity. Biochemistry 38:14542-14548. McIntosh, J.M. B.M. Olivera and L.J. Cruz (1999) Conus peptides as probes for ion channels. Methods Enzymol. 294, 605-624. Quiram, P.A., J.M. McIntosh and S.M. Sine (2000) Pairwise interactions between neuronal alpha7 acetylcholine receptors and α-conotoxin PnIB. J. Biol. Chem. 275:4889-4896. Cho, J., K.H. Mok, B.M. Olivera, J.M. McIntosh, K. Park and K. Han (2000) NMR solution conformation of a- conotoxin AuIB, an α3β4 subtype-selective neuronal nicotinic acetylcholine receptor antagonist. J. Biol. Chem. 275:8680-8685. McIntosh, J.M., S. Gardner, S. Luo, J.E. Garrett and D. Yoshikami (2000) Conus peptides: novel probes for nicotinic acetylcholine receptor structure and function. Eur. J. Pharmacol. 393:205-208. Vailati, S., M. Moretti, B. Balestra, M. McIntosh, F. Clementi and C. Gotti (2000) β3 subunit is present in different nicotinic receptor subtypes in chick retina. Eur. J. Pharmacol. 393:23-30. Whiteaker, P., J.M. McIntosh, S. Luo, A.C. Collins and M.J. Marks (2000) 125Iα-Conotoxin MII dentifies a novel nicotinic acetylcholine receptor population in mouse brain. Mol. Pharmacol. 57:913-925. Bibevski, S., Y. Zhou, J.M. McIntosh, R.E. Zigmond and M.E. Dunlap (2000) Functional nicotinic acetylcholine receptors that mediate ganglionic transmission in cardiac parasympathetic neurons. J. Neurosci. 29:5976- 5982. Oppenheim, R.W., D. Prevette, A. D'Costa, S. Wang, L.J. Houenou and J.M. McIntosh (2000) Reduction of neuromuscular activity is required for the rescue of motoneurons from naturally occurring cell death by nicotinic blocking agents. J. Neurosci. 20:6117-6124. McIntosh, J.M., G.O. Corpuz, R.T. Lyaer, J.E. Garrett, J.D. Wagstaff, G. Bulaj, A. Vyazovkina, D. Yoshikami, L.J. Cruz and B.M. Olivera (2000) Isolation and characterization of a novel Conus peptide with apparent antinociceptive activity. J. Biol. Chem. 275:32391-97. Whiteaker, P., M. Jimenez, J.M. McIntosh, A.C. Collins and M.J. Marks (2000) Identification of a novel nicotinic binding site in mouse brain using [125I]-epibatidine. Br. J. Pharmacol. 131:729-39. Grady, S.R., N.M. Meinerz, J. Cao, A.M. Reynolds, M.R. Picciotto, J.P. Changeux, J.M. McIntosh, M.J. Marks ad A.C. Collins (2001) Nicotinic agonists stimulate actylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum. J. Neurochem. 76:258-68. Quik, M., Y. Polonskaya, J.M. Kulak and J.M. McIntosh (2001) Vulnerability of 125I-α-conotoxin MII binding sites to nigrostriatal damage in monkeys. J. Neurosci.21(15):5494-5500. Barabino, B., S. Vailati, M. Moretti, J.M. McIntosh, R. Longhi, F. Clementi and C. Gotti (2001) An α4β4 nicotinic receptor subtype is present in chick retina; identification, characterization and pharmacological comparison with the transfected α4β4 and α6β4 subtypes. Mol. Pharmacol. 59:1410-17. Jones, R.M., G.E. Cartier, J.M. McIntosh, G. Bulaj, V.E. Farrar and B.M. Olivera (2001) Composition and therapeutic utility of conotoxins from genus Conus. Patent status 1996-2000. Exp. Opin. Ther. Patents 11:603-23. Kulak, J.M., J.M. McIntosh, D. Yoshikami and B.M. Olivera (2001) Nicotine-evoked transmitter release from synaptosomes: functional association of specific presynaptic acetylcholine receptors and voltage-gated calcium channels. J. Neurochem. 77:1581-89. Nayak S.V., J.J. Dougherty, J.M. McIntosh and R.A. Nichols (2001) Ca2+ changes induced by different presynaptic nicotinic receptors in separate populations of individual striatal nerve terminals. J. Neurochem. 76:1860-70. Park, K.H., J. Suk, R. Jacobsen, W.W. Gray, J.M. McIntosh and K.H. Han (2001) Solution conformation of α-conotoxin EI, a neuromuscular toxin specific for the α1/δ subunit interface of Torpedo nicotinic acetylcholine receptor. J. Biol. Chem. 276:49028-33. Champtiaux, N., Z.-Y. Han, A. Bessis, F.M. Rossi, M. Zoli, L. Marubio, J.M. McIntosh and J.-P. Changeux (2002) Distribution and pharmacology of α6-containing nicotinic acetylcholine receptors analysed with mutant mice. J. Neurosci. 22:1208-17. Grady, S.R., K.L. Murphy, J. Cao, M.J. Marks, J.M. McIntosh and A.C. Collins (2002) Characterization of nicotinic agonist-induced [3H]dopamine release from synaptosomes prepared from four mouse brain regions. J. Pharmacol. Exp. Ther. 301:651-60. Kulak, J.M., J. Sum, J.L. Musachio, J.M. McIntosh and M. Quik (2002) 5-Iodo-A-85380 binds to α-conotoxin MII-sensitive nicotinic acetylcholine receptors (nAChRs) as well as α4β2* subtypes. J. Neurochem. 81:403-06. Kulak, J.M., J.L. Musachio, J.M. McIntosh and M. Quik (2002) Declines in different β2* nicotinic receptor populations in monkey striatum after nigrostriatal damage. J. Pharmacol. Exp. Ther. 303:633-39. Kulak, J.M., J.M. McIntosh and M. Quik (2002) Loss of nicotinic receptors in monkey striatum after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment is due to a decline in α-conotoxin MII sites. Mol. Pharmacol. 61:230-38. Marks, M.J., P. Whitaker, S.R. Grady, M.R. Picciotto, J.M. McIntosh and A.C. Collins (2002) Characterization of [125I]epibatidine binding and nicotinic agonist-mediated 86Rb+ efflux in interpeduncular nucleus and inferior colliculus of β2 null mutant mice. J. Neurochem. 81:1102-15. McIntosh, J.M., C. Dowell, M. Watkins, J.E. Garrett, D. Yoshikami and B.M. Olivera (2002) α-Conotoxin GIC from Conus geographus, a novel peptide antagonist of nicotinic acetylcholine receptors. J. Biol. Chem. 277:33610-15. Mogg, A.J., P. Whiteaker, J.M. McIntosh, M. Marks, A.C. Collins and S. Wonnacott (2002) Methyllycaconitine is a potent antagonist of α-conotoxin-MII-sensitive presynaptic nicotinic acetylcholine receptors in rat striatum. J. Pharmacol. Exp. Ther. 302:197-204. Quik, M., Y. Polonskaya, J.M. McIntosh and J.M. Kulak (2002) Differential nicotinic receptor expression in monkey basil ganglia: effects of nigrostriatal damage. Neuroscience 112:619-30. Whiteaker, P., C.G. Peterson, W. Xu, J.M. McIntosh, R. Paylor, A.L. Beaudet, A.C. Collins and M.J. Marks (2002) Involvement of the α3 subunit in central nicotinic binding populations. J. Neurosci. 22:2522-29. Zoli, M., M. Moretti, A. Zanardi, J.M. McIntosh, F. Clementi and C. Gotti (2002) Identification of the nicotinic receptor subtypes expressed on dopaminergic terminals in the rat striatum. J. Neurosci. 22:8785-89. Champtiaux, N., C. Gotti, M. Cordero-Erausquin, D.J. David, C. Przbylski, C. Lena, F. Clementi, M. Moretti, F.M. Rossi, N. Le Novere, J.M. McIntosh, A.M. Gardier and J.P. Changeux (2003) Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knockout mice. J. Neurosci. 23:7820-29. Chi, S.W., K.H. Park, J.E. Suk, B.M. Olivera, J.M. McIntosh and K.H. Han (2003) Solution conformation of α-conotoxin EIVA, a potent neuromuscular nicotinic acetylcholine receptor antagonist from Conus ermineus. J. Biol. Chem. 278:42208-13. Cui, C., T.K. Booker, R.S. Allen, S.R. Grady, P. Whiteaker, M.J. Marks, O. Salminen, T. Tritto, C.M. Butt, W.R. Allen, J.A. Stitzel, J.M. McIntosh, J. Boulter, A.C. Collins and S.F. Heinemann (2003) The β3 nicotinic receptor subunit: a component of α-conotoxin MII binding nAChRs which modulate dopamine release and related behaviors. J. Neurosci. 23:11045-53. Dowell, C., B.M. Olivera, J.E. Garrett, S.T. Saheli, M. Watkins, A. Kuryatov, D. Yoshikami, J.M. Lindstrom and J.M. McIntosh (2003) α-Conotoxin PIA is selective for α6 subunit-containing nicotinic acetylcholine receptors. J. Neurosci. 23:9445-52. Ellison, M., J.M. McIntosh and B.M. Olivera (2003) α-Conotoxins ImI and ImII. Similar α7 nicotinic receptor antagonists act at different sites. J. Biol. Chem. 278:757-64. Everhart, D., E. Reiller, A. Mirzoian, J.M. McIntosh and C.W. Luetje (2003) Identification of residues that confer α-conotoxin PnIA sensitivity on the α3 subunit of neuronal nicotinic acetylcholine receptors. J. Pharmacol. Exp. Ther. 306:664-70. Higashi, T., J.M. McIntosh and M. Shirahata (2003) Characterization of nicotinic acetylcholine receptors in cultured arterial chemoreceptor cells of the cat. Brain Res. 974:167-75. Higashi, T., S. Yamaguchi, J.M. McIntosh and M. Shirahata (2003) Nicotinic acetylcholine receptor channels in cat chemoreceptor cells. Adv. Exp. Med. Biol. 536:285-90. Marubio, L.M., A.M. Gardier, S. Durier, D. David, R. Klink, M.M. Arroyo-Jiminez, J.M. McIntosh, F. Rossi, N. Champtiaux, M. Zoli and J.P. Changeux (2003) Effects of nicotine in the dopaminergic system of mice lacking the α4 subunit of neuronal nicotinic acetylcholine receptors. Eur. J. Neurosci. 17:1329-37. Nai, Q., J.M. McIntosh and J.F. Margiotta (2003) Relating neuronal nicotinic acetylcholine receptor subtypes by subunit composition and channel function. Mol. Pharmacol. 63:311-24. Quik, M., J.D. Sum, P. Whiteaker, S.E. McCallum, M.J. Marks, J. Musachio, J.M. McIntosh, A.C. Collines and S.R. Grady (2003) Differential declines in striatal nicotinic receptor subtype function after nigrostriatal damage in mice. Mol. Pharmacol. 1169-79. Quik, M., T. Bordia, M. Okihara, H. Fan, M.J. Marks, J.M. McIntosh and P. Whiteaker (2003) L-DOPA treatment modulates nicotinic receptors in monkey striatum. Mol. Pharmacol. 64:619-28. Amtage, F., B. Neughebauer, J.M. McIntosh, T. Freiman, J. Zentner, T.J. Feuerstein and R. Jackisch (2004) Characterization of nicotinic receptors inducing noradrenaline release and absence of nicotinic autoreceptors in human neocortex. Brain Res. Bull. 62:413-23. Chi, S.W., D.H. Kim, B.M. Olivera, J.M. McIntosh and K.H. Han (2004) Solution conformation of α-conotoxin GIC, a novel potent antagonist of α3β2 nicotinic acetylcholine receptors. Biochem. J. 380:347-52. Ellison, M., F. Gao, H.-L. Wang, S.M. Sine, J.M. McIntosh and B.M. Olivera (2004) α-Conotoxins ImI and ImII interact with different residues of the α7 nAChR and have different nAChR selectivities. Biochemistry 43:16019-26. Everhart, D., G.E. Cartier, A. Malhotra, A.V. Gomes, J.M. McIntosh and C.W. Luetje (2004) Determinants of potency on α-conotoxin MII, a peptide antagonist of neuronal nicotinic receptors. Biochemistry 43:2732-37. Lai, A., J. Sum, H. Fan, J.M. McIntosh and M. Quik (2004) Selective recovery of striatal 125I-α conotoxin MII nicotinic receptors after nigrostriatal damage in monkeys. Neuroscience 127:399-408. Luo, S. and J.M. McIntosh (2004) Iodo-α-conotoxin MI selectively binds the α/ δ subunit interface of muscle nicotinic acetylcholine receptors. Biochemistry 43:6656-62. McIntosh, J.M., L. Azam, S. Staheli, C. Dowell, J.M. Lindstrom, Al. Kuryatov, J.E. Garrett, M.J. Marks and P. Whiteaker (2004) Analogs of α-conotoxin MII are selective for α6-containing nAChRs. Mol. Pharmacol. 65:944-52. Parker, S.L., Y. Fu, K. McAllen, J. Luo, J.M. McIntosh, J.M. Lindstrom and B.M. Sharp (2004) Up-regulation of brain nicotinic acetylcholine receptors in the rat during long-term self-administration of nicotine: disproportionate increase of the α6 subunit. Mol. Pharmacol. 65:611-22. Quik, J., T. Bordia, L. Forno and J.M. McIntosh (2004) Loss of α-conotoxin MII- and A85380-sensitive nicotinic receptors in Parkinson's disease striatum. J. Neurochem. 88:668-79. Ray, M., I. Bohr, J.M. McIntosh, C. Ballard, I. McKeith, S. Chalon, D. Guilloteau, R. Perry, E. Perry, J. Court and M. Piggott (2004) Involvement of α6/α3 neuronal nicotinic acetylcholine receptors in neuropsychiatric features of Dementia with Lewy bodies: [125I] α-conotoxin MII binding in the thalamus and striatum. Neurosci. Lett. 372:220-25. Salminen, O., K.L. Murphy, J.M. McIntosh, J. Drago, M.J. Marks, A.C. Collins and S.R. Grady (2004) Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice. Mol. Pharmacol. 65:126-35. Santos, A.D., J.M. McIntosh, D.R. Hillyard, L.J. Cruz and B.M. Olivera (2004) The A-superfamily of conotoxins: structural and functional divergence. J. Biol. Chem. 279:17596-606. Azam, L., C. Dowell, M. Watkins, J.A. Stitzel, B.M. Olivera and J.M. McIntosh (2005) α-Conotoxin BuIA, a novel peptide from Conus bullatus distinguishes among neuronal nicotinic acetylcholine receptors. J. Biol. Chem. 280:80-87. Azam, L. and J.M. McIntosh (2005) Effect of novel α-conotoxins on nicotine-stimulated [3H]dopamine release from rat striatal synaptosomes. J. Pharmacol. Exp. Ther. 312:231-37. Bohr, I.J., M.A. Ray, J.M. McIntosh, S. Chalon, D. Guilloteau, I.G. McKeith, R.H. Perry, F. Clementi, E.K. Perry, J.A. Court and M.A. Piggott (2005) Cholinergic nicotinic receptor involvement in movement disorders associated with Lewy body diseases. An autoradiography study using [125I] α-conotoxin MII in the striatum and thalamus. Exp. Neurol. 191:292-300. Corpuz, G.P., R.B. Jacobsen, E.C. Jimenez, M. Watkins, C. Walker, C. Colledge, J.E. Garrett, O. McDougal, W. Li, W.R. Gray, D.R. Hillyard, J. Rivier, J.M. McIntosh, L.J. Cruz and B.M. Olivera (2005) Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms. Biochemistry 44:8176-86. Gotti, C., M. Moretti, F. Clementi, L. Riganti, J.M. McIntosh, A.C. Collins, M.J. Marks and P. Whiteaker (2005) Expression of nigrostriatal α6-containing nicotinic acetylcholine receptors is selectively reduced, but not eliminated, by β3 subunit gene deletion. Mol. Pharmacol. 67:2007-15. Lai, A., N. Parameswaran, M. Khwaja, P. Whiteaker, J.M. Lindstrom, H. Fan, J.M. McIntosh, S.R. Grady and M. Quik (2005) Long-term nicotine treatment decreases striatal α6* nAChR sites and function in mice. Mol. Pharmacol. 67:1639-47. McCallum, S.E., N. Parameswaran, T. Bordia, J.M. McIntosh, S.R. Grady and M. Quik (2005) Decrease in α3*/α6* nicotinic receptors but not nicotine-evoked dopamine release in monkey brain after nigrostriatal damage. Mol. Pharmacol., Jun 2 [Epub ahead of print]. Quik, M., S. Vailati, T. Bordia, J.M. Kulak, H. Fan, J.M. McIntosh, F. Clementi, and C. Gotti (2005) Subunit composition of nicotinic receptors in monkey striatum: effect of treatments with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or L-DOPA. Mol. Pharmacol. 67:32-41. Salminen, O., P. Whiteaker, S.R. Grady, A.C. Collins, J.M. McIntosh and M.J. Marks (2005) The subunit composition and pharmacology of α-conotoxin-MII-binding nicotinic acetylcholine receptors studied by a novel membrane-binding assay. Neuropharmacology 48:696-705. Zhu P.J., R.R. Stewart, J.M. McIntosh, F.F. Weight. Activation of Nicotinic Acetylcholine Receptors Increases the Frequency of Spontaneous GABAergic IPSCs in Rat Basolateral Amygdala Neurons. J Neurophysiol. 2005 Nov;94(5):3081-91. Marritt, A.M., B.C. Cox, R. Yasuda, Y. Xiao, J.M. McIntosh, B.B. Wolfe, K.J. Kellar (2005) Nicotinic Cholinergic Receptors in the Rat Retina: Simple and Mixed Heteromeric Subtypes. Mol Pharmacol.; Mol Pharmacol 68, 1656-68. Azam, L., and J.M. McIntosh (2006). Characterization of nicotinic acetylcholine receptors that modulate nicotine-evoked [3H]norepinephrine release from mouse hippocampal synaptosomes. Mol Pharmacol 70, 967-76. Bordia, T., N. Parameswaran, H. Fan, J. W. Langston, J.M. McIntosh, and M. Quik (2006). Partial recovery of striatal nicotinic receptors in 1-methyl -4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned monkeys with chronic oral nicotine. J Pharmacol Exp Ther 319, 285-92. Chi, S. W., D. H. Kim, B. M. Olivera, J.M. McIntosh, and K. H. Han (2006). NMR structure determination of α-conotoxin BuIA, a novel neuronal nicotinic acetylcholine receptor antagonist with an unusual 4/4 disulfide scaffold. Biochem Biophys Res Commun 349, 1228-34. Chi, S. W., D. H. Kim, B. M. Olivera, J.M. McIntosh, and K. H. Han (2006). Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist α-conotoxin OmIA that discriminates α3 vs. α6 nAChR subtypes. Biochem Biophys Res Commun 345, 248-54. Ellison, M., C. Haberlandt, M. E. Gomez-Casati, M. Watkins, A. B. Elgoyhen, J.M. McIntosh, and B. M. Olivera (2006). α-RgIA: a novel conotoxin that specifically and potently blocks the (9(10 nAChR. Biochemistry 45, 1511-7. Kamendi, H., C. Stephens, O. Dergacheva, X. Wang, Z. G. Huang, E. Bouairi, C. Gorini, J.M. McIntosh, and D. Mendelowitz (2006). Prenatal nicotine exposure alters the nicotinic receptor subtypes that modulate excitation of parasympathetic cardiac neurons in the nucleus ambiguus from primarily α3β2 and/or α α β βX to α3β4. Neuropharmacology 51, 60-6. Loffler, M., B. Bubl, F. Huethe, U. Hubbe, J.M. McIntosh, R. Jackisch, and T. J. Feuerstein (2006). Dopamine release in human neocortical slices: characterization of inhibitory autoreceptors and of nicotinic acetylcholine receptor-evoked release. Brain Res Bull 68, 361-73. McCallum, S. E., N. Parameswaran, T. Bordia, H. Fan, J.M. McIntosh, and M. Quik (2006). Differential regulation of mesolimbic α3/α6β2 and α4β2 nicotinic acetylcholine receptor sites and function after long-term oral nicotine to monkeys. J Pharmacol Exp Ther 318, 381-8. McCallum, S. E., N. Parameswaran, T. Bordia, H. Fan, R. F. Tyndale, J. W. Langston, J.M. McIntosh, and M. Quik (2006). Increases in α4* but not α3*/α6* nicotinic receptor sites and function in the primate striatum following chronic oral nicotine treatment. J Neurochem 96, 1028-41. McCallum, S. E., N. Parameswaran, X. A. Perez, S. Bao, J.M. McIntosh, S. R. Grady, and M. Quik (2006). Compensation in pre-synaptic dopaminergic function following nigrostriatal damage in primates. J Neurochem 96, 960-72. Quik M. and J.M. McIntosh (2006) Striatal α6* nicotinic acetylcholine receptors: potential targets for Parkinson's disease therapy. J Pharmacol Exp Ther;316(2):481-9. Shiembob, D. L., R. L. Roberts, C. W. Luetje, and J.M. McIntosh (2006). Determinants of α-conotoxin BuIA selectivity on the nicotinic acetylcholine receptor β subunit. Biochemistry 45, 11200-7. Talley, T. T., B. M. Olivera, K. H. Han, S. B. Christensen, C. Dowell, I. Tsigelny, K. Y. Ho, P. Taylor , and J.M. McIntosh (2006). α-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as α3β2 and α7 nicotinic acetylcholine receptors. J Biol Chem 281, 24678-86. Vincler, M., S. Wittenauer, R. Parker, M. Ellison, B. M. Olivera, and J.M. McIntosh (2006). Molecular mechanism for analgesia involving specific antagonism of α9α10 nicotinic acetylcholine receptors. Proc Natl Acad Sci U S A 103, 17880-4. Vishwanath V.A. and J.M. McIntosh (2006) Synthesis of fluorescent analogs of α-conotoxin MII. Bioconjug Chem;17(6):1612-7. Bordia T., S.R. Grady, J.M. McIntosh and M. Quik (2007) Nigrostriatal damage preferentially decreases a subpopulation of α6β2* nAChRs in mouse, monkey, and Parkinson's disease striatum. Mol Pharmacol; 72(1): 52-61. Bouvrais-Veret C., S. Weiss, A. Andrieux, A. Schweitzer, J.M. McIntosh, D. Job, B. Giros and M. P. Martres (2007) Sustained increase of a7 nicotinic receptors and choline-induced improvement of learning deficit in STOP knock-out mice. Neuropharmacology; 52(8): 1691-700. Khwaja M., A. McCormack, J.M. McIntosh, D. A. Di Monte and M. Quik (2007) Nicotine partially protects against paraquat-induced nigrostriatal damage in mice; link to α6β2* nAChRs. J Neurochem; 100(1): 180-90. Perry D. C., D. Mao, A. B. Gold, J.M. McIntosh, J. C. Pezzullo and K.J. Kellar (2007) Chronic nicotine differentially regulates α6- and β3-containing nicotinic cholinergic receptors in rat brain. J Pharmacol Exp Ther; 322(1): 306-15. Salminen O., J. A. Drapeau, J.M. McIntosh, A. C. Collins, M. J. Marks and S.R. Grady (2007) Pharmacology of α-conotoxin MII-sensitive subtypes of nicotinic acetylcholine receptors isolated by breeding of null mutant mice. Mol Pharmacol; 71(6):1563-71. Scholze P., A. Orr-Urtreger, J. P. Changeux, J.M. McIntosh, S. Huck (2007) Catecholamine outflow from mouse and rat brain slice preparations evoked by nicotinic acetylcholine receptor activation and electrical field stimulation. Br J Pharmacol; 151(3):414-22. Weiss S., M. Nosten-Bertrand, J.M. McIntosh, B. Giros, M. P. Martres (2007) Nicotine Improves Cognitive Deficits of Dopamine Transporter Knockout Mice without Long-Term Tolerance. Neuropsychopharmacology. Whiteaker P., S. Christensen, D. Yoshikami, C. Dowell, M. Watkins, J. Gulyas and J.M. McIntosh (2007). Discovery, Synthesis, and Structure Activity of a Highly Selective α7 Nicotinic Acetylcholine Receptor Antagonist. Biochemistry; 46(22): 6628-38. Vincler M, McIntosh J.M. Targeting the α9α10 nicotine acetylcholine receptor to treat severe pain. Expert Opin Ther Targets. 2007 11(7): 891-7. Löf E, Olausson P, deBejczy A, Stomberg R, McIntosh JM, Taylor JR, Söderpalm B.Nicotinic acetylcholine receptors in the ventral tegmental area mediate the dopamine activating and reinforcing properties of ethanol cues. Psychopharmacology (Berl) . (2007) 195(3): 333-43. Grady SR, Salminen O, Laverty DC, Whiteaker P, McIntosh JM, Collins AC, Marks MJ.The subtypes of nicotinic acetylcholine receptors on dopaminergic terminals of mouse striatum. Biochem Pharmacol. (2007) 74(8): 1235-46. Teper Y, Whyte D, Cahir E, Lester HA, Grady SR, Marks MJ, Cohen BN, Fonck C, McClure-Begley T, McIntosh JM, Labarca C, Lawrence A, Chen F, Gantois I, Davies PJ, Petrou S, Murphy M, Waddington J, Horne MK, Berkovic SF, Drago J. Nicotine-induced dystonic arousal complex in a mouse line harboring a human autosomal-dominant nocturnal frontal lobe epilepsy mutation. J Neurosci. (2007) 27(38): 10128-42. Exley R, Clements MA, Hartung H, McIntosh JM, Cragg SJ. α6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens. Neuropsychopharmacology. (2008) 33(9): 2158-66. Meyer EL, Yoshikami D, McIntosh JM. The neuronal nicotinic acetylcholine receptors α4* and α6* differentially modulate dopamine release in mouse striatal slices. J Neurochem. (2008) 105(5): 1761-9. Ellison M, Feng ZP, Park AJ, Zhang X, Olivera BM, McIntosh JM, Norton RS. α-RgIA, a novel conotoxin that blocks the α9α10 nAChR: structure and identification of key receptor-binding residues. J Mol Biol. (2008) 377(4): 1216-27. Azam L, Yoshikami D, McIntosh JM. Amino acid residues that confer high selectivity of the α6 nicotinic acetylcholine receptor subunit to α-conotoxin MII [S4A, E11A, L15A]. J Biol Chem. (2008) 283(17): 11625-32. O'Leary K, Parameswaran N, McIntosh JM, Quik M. Cotinine selectively activates a subpopulation of α3/α6β2 nicotinic receptors in monkey striatum. J Pharmacol Ther. (2008) 325(2): 646-54. Whiteaker P, Marks MJ, Christensen S, Dowell C, Collins AC, McIntosh JM. Synthesis and characterization of 125I-α-conotoxin ArIB[V11L;V16A], a selective α7 nicotinic acetylcholine receptor antagonist. J Pharmacol Ther. (2008) 325(3): 910-9. Papke RL, Dwoskin LP, Crooks PA, Zheng G, Zhang Z, McIntosh JM, Stokes C. Extending the analysis of nicotinic receptor antagonists with the study of α6 nicotinic receptor subunit chimeras. Neuropharmacology. (2008) 54(8): 1189-200. Dwoskin LP, Wooters TE, Sumithran SP, Siripurapu KB, Joyce BM, Lockman PR, Manda VK, Ayers JT, Zhang Z, Deaciuc AG, McIntosh JM, Crooks PA, Bardo MT. N, N'-Alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: inhibition of nicotine-evoked dopamine release and hyperactivity. J Pharmacol Exp Ther. (2008) Aug; 326(2): 563-76. Perez XA, Bordia T, McIntosh JM, Grady SR, Quik M. Long-term nicotine treatment differentially regulates striatal a6a4(2* and a6_(non-a4) (2* nAChR expression and function. Mol Pharmacol. (2008) 74(3): 844-53. O'Leary KT, Parameswaran N, Johnston LC, McIntosh JM, Di Monte DA, Quik M. Paraquat exposure reduces nicotinic receptor-evoked dopamine release in monkey striatum. J Pharmacol Exp Ther. 2008 [In Press] Young T, Wittenauer S, McIntosh JM, Vincler M. Spinal α3β2* nicotinic acetylcholine receptors tonically inhibit the transmission of nociceptive mechanical stimuli. Brain Res. (2008) 1229:118-24. Innocent N, Livingstone PD, Hone A, Kimura A, Young T, Whiteaker P, McIntosh JM, Wonnacott S. Conotoxin ArIB[V11L,V16D] is a potent and selective antagonist at rat and human native α7 nicotinic acetylcholine receptors. J Pharmacol Exp Ther. 2008 [in Press] Book Chapters Olivera, B.M., J.M. McIntosh and L.J. Cruz (1993) Conus peptides as tools for the neuroscientist. In: Gene -Brain -Behaviour, Proceedings of the 21st Göttingen Neurobiology Conference (Elsner, N. and M. Heisenberg, eds.), Georg Thieme Verlag, Stuttgart, New York, pp 159- 169. Craig, A.G., W.H. Fischer, J.E. Rivier, J.M. McIntosh and W.R. Gray (1995) MS based scanning methodologies applied to Conus venom. In: Technologies in Protein Chemistry VI (J.W. Crabb, ed.), Academic Press, San Diego, CA, pp 31-38. McIntosh, J.M. (1996) a-Conotoxins and nicotinic acetylcholine receptors. In: Aspects in Marine Pharmacology (P. Lazarovici, M. Spira and E. Zlotkin, eds.), Fort Collins Colorado, Alaken Inc., pp 28-33. Cruz, L.J., J.M. McIntosh, J.S. Imperial and W.R. Gray (1999) Conus peptides and their iodinated derivatives as probes for ion channels and receptors. In: Animal Toxins - Facts and Protocols (H. Rochat, M.-F. Martin-Eauclaire, eds.), Birkhäuser Verlag, Basel, Switzerland, pp 74-89. McIntosh, J.M. (2000) Toxin antagonists of the neuronal nicotinic acetylcholine receptor. In: Neuronal Nicotinic Receptors (F. Clementi, D. Fornasari and C. Gotti, eds.), Springer-Verlag, Berlin, pp 455-476.

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