J. Michael McIntosh Research Professor, and Professor and Director of Research, Dept. of Psychiatry mcintosh dot mike at gmail dot com McIntosh lab web site McIntosh lab directory

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RESEARCH INTERESTS Receptors and ion channels, Neuroscience, Neuropharmacology Modulation of neurotransmitter release Isolation & biochemical characterization of peptides that target nicotinic acetycholine receptors Functional structure of conotoxins Nicotinic receptors in Parkinson's Disease Development of novel medications PUBLICATIONS We are interested in the isolation and biochemical characterization of compounds that selectively act on the nervous system. These probes are used to study the structure and function of central nervous system receptors and ion channels in both health and disease states. Structure/function analysis of these ligands provides opportunity for drug development of selected compounds. Currently these compounds are being investigated for the treatment of chronic pain, epilepsy, cardiovascular disorders and neuropsychiatric disorders. Selected Publications Kulak, J.M., T.A. Nguyen, B.M. Olivera and J.M. McIntosh (1997) a-Conotoxin MII blocks nicotine-stimulated dopamine release in rat striatal synaptosomes. J. Neurosci. 17:5263-70. Luo, S., J.M. Kulak, G.E. Cartier, R.B. Jacobsen, D. Yoshikami, B.M. Olivera and J.M. McIntosh (1998) a- Conotoxin AuIB selectively blocks a3b4 nicotinic acetylcholine receptors and nicotine-evoked norepinephrine release. J. Neurosci. 18:8571-79. McIntosh, J.M., A.D. Santos and B.M. Olivera (1999) Conus peptides targeted to specific nicotinic acetylcholine receptor subtypes. Annu. Rev. Biochem. 68:59-88. Whiteaker, P., J.M. McIntosh, S. Luo, A.C. Collins and M.J. Marks (2000) 125I-a-Conotoxin MII identifies a novel nicotinic acetylcholine receptor population in mouse brain. Mol. Pharmacol. 57:913-25. Oppenheim, R.W., D. Prevette, A. D'Costa, S. Wang, L.J. Houenou and J.M. McIntosh (2000) Reduction of neuromuscular activity is required for the rescue of motoneurons from naturally occurring cell death by nicotinic blocking agents. J. Neurosci. 20:6117-24. Quik, M., Y. Polonskaya, J.M. Kulak and J.M. McIntosh (2001) Vulnerability of 125I-a-conotoxin MII binding sites to nigrostriatal damage in monkeys. J. Neurosci.21(15):5494-5500.

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