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RESEARCH INTERESTS
2007 Nobel Laureate in Physiology & Medicine
Howard Hughes Medical Institute Investigator
University of Utah School of Medicine
Developmental genetics; gene targeting; human inherited disease
PUBLICATIONS
Homologous recombination between DNA sequences residing
in the chromosome and newly introduced DNA sequences,
termed gene targeting, provides the means for specifically
modifying any gene in any desired manner in cultured
mammalian cells. If the recipient cell for the gene
modification is a pluripotent, mouse embryo-derived stem
cell, then the means are available for creating chimeric mice
from these cells that will transfer the altered gene to their
progeny. With this technology, the biological function of any
cloned gene can be determined in the living mouse.
We are using this technology to genetically dissect
early development in the mouse. Our efforts are directed
towards determining the function of two sets of genes in
development. The first set is involved in localized
developmental decision through cell-cell signaling. The
second set includes members of a transcriptional
developmental program that specify positional value in the
early mouse embryo.
Selected Publications
Capecchi, M.R. 1989. The new mouse genetics: altering the
genome by gene targeting. Trends in Genetics 5:
70-76.
Capecchi, M.R. 1989. Altering the genome by homologous
recombination. Science 244:1288-1292.
Thomas, K.R., and M.R. Capecchi. 1990. Targeted
disruption of the murine int-1 proto-oncogene
resulting in severe abnormalities in midbrain and cerebellar
development. Nature 346:847-850.
Chisaka, O. and M.R. Capecchi. 1991. Regionally restricted
developmental defects resulting from targeted disruption of
the mouse homeobox gene hox-1.5. Nature 350:
473-479.
Chisaka, O., T.S. Musci, and M.R. Capecchi. 1992.
Developmental defects of the ear, cranial nerves and
hindbrain resulting from targeted disruption of the mouse
homeobox gene hox-1.6. Nature 355:516-520.
Godwin, A.R., H.S. Stadler, K. Nakamura and M.R. Capecchi.
1998. Detection of targeted GFP-Hox gene fusions
1999. during mouse embryogenesis. Proc. Natl. Acad. Sci.
2000. USA 95:13042-13047.
Rossel, M. and M.R. Capecchi. 1999. Mice mutant for both
Hoxa1 and Hoxb1 show extensive remodeling
of the hindbrain and defects in craniofacial development.
Development 126:5027-5040.
Greer, J.M., J. Puetz, K.R. Thomas and M.R. Capecchi. 2000.
Maintenance of functional equivalence during paralogous
Hox gene evolution. Nature 403:
661-665.
Barrow, J.R., H.S. Stadler and M.R. Capecchi. 2000. Roles of
Hoxa1 and Hoxa2 in patterning the early
hindbrain of the mouse. Development 127:
933-944.
Capecchi, M.R. 1994. Targeted gene replacement.
Sci. Am. 270:54-61.
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