My research involves the pharmacological study of ligand-gated and voltage-gated ion channels involved in function and disorders of the mammalian nervous system. I am especially interested in neuronal nicotinic acetylcholine receptors, AMPA-type glutamate receptors and voltage-gated calcium channels. Currently, I am using fast-scan cyclic voltammetry to study the regulation of catecholamine release by nicotinic receptors in specific regions of mouse brain.
Selected Publications
Gahring, L.C.; Persiyanov K.; Dunn D.; Weiss R.; Meyer, E.L.; Rogers, S.W. (2004) Mouse strain-specific nicotinic acetylcholine receptor expression by inhibitory interneurons and astrocytes in the dorsal hippocampus. J. Comp. Neurol. 468, 334-346.
Meyer, E.L.; Strutz, N.; Gahring, L.C.; Rogers, S.W. (2003) Glutamate receptor subunit 3 is modified by site-specific limited proteolysis including cleavage by gamma-secretase; J. Biol. Chem. 278, 23786-23796.
Meyer, E.L.; Gahring, L.C.; Rogers, S.W. (2002) Nicotine preconditioning antagonizes activity-dependent caspase proteolysis of a glutamate receptor; J. Biol. Chem. 277, 10869-10875.
Gahring, L.C.; Carlson, N.G.;Meyer, E.L.; Rogers, S.W. (2001) Cutting Edge: Granzyme B proteolysis of a neuronal glutamate receptor generates an autoantigen and is modulated by glycosylation; J. Immunol. 166,1433-1438.
Gahring, L.C.; Meyer, E.L.; Rogers, S.W. (2003) Nicotine-induced neuroprotection against N-methyl-D-aspartic acid or β-amyloid peptide occur through independent mechanisms distinguished by pro-inflammatory cytokines, J. Neurochem. 87, 1125-1136.
Meyer, E.L.; Xiao, Y.; Kellar, K.J. (1999) Pharmacological properties and regulation of the rat neuronal nicotinic acetylcholine receptor α3β4 subtype expressed in the KXα3β4R2 Cell Line; Mol. Pharmacol. 60-3, 568-576.
Xiao, Y.; Meyer, E.L.; Houghtling, R.; Thompson J.; Kellar, K.J. (1998) Generation of mammalian cell lines which stably express rat neuronal nicotinic acetylcholine receptor subtypes; Proceedings of the10th; Springer-Verlag; Editors: Rushan, L.; Niu, S.; Mackay, J.; Peto, R.
Xiao, Y.; Meyer, E.L.; Thompson, J.M.; Surin, A.; Wroblewski, J.; and Kellar, K.J. (1997) Rat α3β4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: pharmacology of ligand binding and function; Mol. Pharmacol. 54, 322-333.
Dickerson, L.; Panico, W.; Kuhn, F.; Willis, A.; FitzGerald, J.; Meyer, E.L.; Norman, W.; Gillis, R. (1997) Stimulation of canine rostral ventrolateral medulla and A5 area changes sympathetic outflow to vascular beds without effects on the heart; American Journal of Physiology, 41, R821-R839.
Vickers, A.E.M.; Algret, M.; Meyer, E.; Smiley, S.; Guertler, J. (1996) Hydroxyethyl cyclosporin A induces and decreases P450A and P-glycoprotein levels in rat liver; Xenobiotica, 26-1, 27-39.
Vickers, A.E.M.; Meyer, E.; Dannecker, R.; Keller, B.; Tynes, R.; Mauer, G. (1994) Human liver CYP3A biotransformation of the cyclosporin derivative SDZ IMM-125; Drug Metabolism and Disposition, 23-3, 321-326.
Gahring, L.C.; Carlson, N.G.; Meyer, E.L.; Rogers, S.W. (2004) Neurodegenerative disease and the neuroimmunology of glutamate receptors. Advances in Molecular and Cell Biology: 32, 139-158 (Chapter7) Elsevier B.V.
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