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Top Photo - University of Utah biologist Baldomero
"Toto" Olivera with a deadly cone snail used in his
research to develop new medicines.
Photo Credit: Steve Wilson/AP copyright HHMI
Bottom Photo - Baldomero "Toto" Olivera, a
University of Utah biologist, is among 20 new "Million-
Dollar Professors" named by the Howard Hughes Medical
Institute in a program that emphasizes teaching to bring
bright young people into science.
Photo Credit: Steve Wilson/AP copyright HHMI
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April 5, 2006 - Baldomero "Toto" Olivera, a
University of Utah biologist who has spent his career
developing new medicines from the toxins of deadly cone
snails, has won a four-year, $1 million award as one of 20
new "Million-Dollar Professors" named by the prestigious
Howard Hughes Medical Institute (HHMI).
The award is different from HHMI's program of designating
researchers as HHMI investigators and paying their
salaries. Instead, the Million-Dollar Professor program
supports professors in their efforts to "ignite the
scientific spark in a new generation of students" through
teaching and mentoring.
Olivera plans to use the money to teach children and
undergraduates from his native Philippines, Hawaii and U.S.
Pacific territories about biodiversity in their
environment, and also to implement a neuroscience program
for undergraduates at the University of Utah.
Below are:
(1) HHMI's news release on the 20 new Million-Dollar
Professors.
(2) HHMI's profile of Olivera, his research and his plans
for the $1 million.
News media wishing to interview Olivera may call him or his
assistant, Carol Bergstrom, at (801) 581-8370 or via email
at
olivera@biology.utah.edu or
bergstrom@biology.utah.edu
A University of Utah web page on Olivera is at:
www.biology.utah.edu/faculty2.php?inum=7
In addition, Cognetix, a spinoff company based on Olivera's
research, has details of its works developing medicines
from cone snail toxins:
www.cognetix.com
Lee Siegel
University of Utah Public Relations
-----------------
(1) News release from the Howard Hughes Medical
Institute
Media contacts:
Jennifer Donovan
(301) 215-8859; donovanj@hhmi.org
Cindy Fox Aisen
(317) 843-2276; aisenc@hhmi.org
HHMI Names 20 New Million-Dollar Professors Top Research
Scientists Tapped for their Teaching Talent
CHEVY CHASE, Maryland, April 5, 2006 - Teaching often takes a
back seat to research at leading American universities.
Determined to change that fact, the Howard Hughes Medical
Institute (HHMI) combed the country for leading research
scientists who, through their teaching and mentoring, are
striving to ignite the scientific spark in a new generation
of students. Now 20 of the best will receive $1 million
each from HHMI to put their innovative ideas into action as
HHMI professors at 18 research universities across the
country.
The Institute does not tell the HHMI professors what to do
or how to approach science education. Rather, HHMI provides
them with the resources to turn their own considerable
creativity loose in their undergraduate classrooms. Some
will design programs to attract more women and minorities
to science. Others will turn large introductory science
courses or classes for non-science majors into engaging,
hands-on learning experiences that challenge students to
think like working scientists.
"The scientists whom we have selected are true pioneers - not
only in their research, but in their creative approaches
and dedication to teaching," said Thomas R. Cech, HHMI
president. "We are hopeful that their educational
experiments will energize undergraduate science education
throughout the nation."
The Institute awarded $20 million to the first group of
HHMI professors in 2002 to bring the excitement of
scientific discovery to the undergraduate classroom.
The experiment worked so well that neurobiologist and HHMI
professor Darcy Kelley convinced Columbia University to
require every entering freshman to take a course on hot
topics in science. Through Utpal Bannerjee's HHMI program
at the University of California, Los Angeles, 138
undergraduates were co-authors of a published a peer-
reviewed article in a top scientific journal. At the
University of Pittsburgh, HHMI professor Graham Hatfull's
undergraduates mentored curious high school students as
they unearthed and analyzed more than 30 never-before-seen
bacteriophages from yards and barnyards. And Isiah Warner,
an award-winning chemist and HHMI professor at Louisiana
State University, developed a "mentoring ladder," a
hierarchical model for integrating research, education, and
peer mentoring, with a special emphasis on underrepresented
minority students.
"The HHMI professors are as excited about teaching as they
are about research, and it definitely rubs off on their
students," said Peter Bruns, HHMI vice president for grants
and special programs. "Undergraduates need a window into
the excitement and fulfillment that scientists get from
science. They need to discover that science is a way of
learning and knowing, involving critical thinking, problem
solving, and asking answerable questions. In this program
we are supporting faculty to use research grade innovation
to advance science education."
The Institute will give smaller renewal grants to eight of
the original 20 professors to help them find ways to
sustain the parts of their programs that worked best and to
disseminate them to the broader community of teachers.
Last year, HHMI invited 100 research universities with
outstanding track records in sending graduates to medical
or graduate school to nominate up to two faculty members to
compete for the HHMI professorships. A panel of
distinguished research scientists and educators, including
some HHMI professors selected in the last competition,
reviewed 150 applications. They evaluated the potential
impact of the proposals on undergraduate science education,
as well as the quality of the applicants" research and
educational accomplishments, and the potential for the
proposed programs to serve as models elsewhere.
The new HHMI professors are accomplished researchers from
diverse fields, including genetics, biochemistry, plant
pathology, bioengineering, neuroscience, biophysics, and
computational biology. Two are members of the National
Academy of Sciences. Two have won Presidential Early Career
Awards.
Some of the professors' plans include:
-- Winston Anderson, a professor of biology at
historically African-American Howard University in
Washington, D.C., wants to give his undergraduates "a
competitive edge" for entering biomedical science careers.
He plans intensive mentoring and a summer exchange program
that will take students to African countries such as Ghana,
Ethiopia, Mali, or Nigeria to study tropical diseases and
ethnopharmacologyÑthe use of indigenous plants for
medicinal purposes.
-- Susan Wessler, a Regents professor of plant
biology at the University of Georgia, intends to respond to
the proponents of "intelligent design" by guiding her
undergraduates through bioinformatic and genetic analyses
of transposable elements in plant genomes, so they can
witness evolution in action. Transposable elements, the
focus of Wessler's research, are pieces of DNA that make
copies of themselves that are inserted throughout the
genomes of plants and animals, at times promoting
evolutionary change.
-- Scott Strobel, a Yale University biophysicist and
biochemist, will take undergraduates "bio-prospecting" for
promising natural products in the world's rain forests. The
students will then purify and analyze the compounds they
collected and test them for potentially beneficial
activity.
The new HHMI professors are:
Name / Institution
Richard Amasino / University of Wisconsin, Madison
Winston Anderson / Howard University
Bonnie Barte / Rice University
Victor Corces / The Johns Hopkins University
Catherine Drennan / Massachusetts Institute of Technology
Irving Epstein / Brandeis University
Louis Guillette, Jr. / University of Florida
Leslie Leinwand / University of Colorado at Boulder
Claudia Neuhauser / University of Minnesota, Twin Cities
Diane O'Dowd / University of California, Irvine
Baldomero Olivera / University of Utah
Pavel Pevzner / University of California, San Diego
Jasper Rine / University of California, Berkeley
Robert Sah / University of California, San Diego
Scott Strobel / Yale University
David Walt / Tufts University
Susan Wessler / University of Georgia
Jennifer West / Rice University
Huntington Willard / Duke University
Richard Zare / Stanford University
The following 2002 HHMI professors received renewal awards:
Name / Institution
Utpal Banerjee / University of California, Los Angeles
Sarah C.R. Elgin / Washington University in St. Louis
Jo Handelsman / University of Wisconsin-Madison
Graham Hatfull / University of Pittsburgh
Darcy Kelley / Columbia University
Richard Losick / Harvard University
Rebecca Richards-Kortum / Rice University
Isiah Warner / Louisiana State University and A&M College
The Howard Hughes Medical Institute is dedicated to
discovering and disseminating new knowledge in the basic
life sciences. HHMI grounds its research programs on the
conviction that scientists of exceptional talent and
imagination will make fundamental contributions of lasting
scientific value and benefit to mankind when given the
resources, time, and freedom to pursue challenging
questions. The Institute prizes intellectual daring and
seeks to preserve the autonomy of its scientists as they
pursue their research.
A nonprofit medical research organization, HHMI was
established in 1953 by the aviator-industrialist. The
Institute, headquartered in Chevy Chase, Maryland, is one
of the largest philanthropies in the world with an
endowment of $14.8 billion at the close of its 2005 fiscal
year. HHMI spent $483 million in support of biomedical
research and $80 million for support of a variety of
science education and other grants programs in fiscal 2005.
(2) Profile of Baldomero "Toto" Olivera from the Howard
Hughes Medical Institute
Toto's Cone Snails
Growing up in the Philippines, Baldomero "Toto" Olivera
recalls that cone snails were sold by the kilo in local
seafood markets. As a child, however, Olivera was
blissfully unaware of the impact that the predatory cone
snail, Conus magus, would have on his life's work. Nor
could he have imagined that the creatures would even enable
his lab to develop a drug to bring relief to people in
chronic pain.
Now a distinguished professor of biology and neuroscientist
at the University of Utah in Salt Lake City, Olivera was
nicknamed Toto by a cousin who could not pronounce Totoy, a
pet name sometimes given to Filipino boys. As an HHMI
professor, he plans to take the story of the cone snail
back to the children of the Philippines and the nearby
Pacific islands the snails inhabit. "These snails have so
much potential, and the children don't know anything about
their biology," he explained.
Olivera will teach children and undergraduates from the
Philippines, Hawaii, and U.S. territories in the Pacific
about the richness of their surroundings through a project
he calls the Biodiversity-Biomedical Links Initiative. "My
idea is to concentrate on the biodiversity that's at their
feet," he said. His goal is to interest young students by
educating them about scientific principles that can be
observed in organisms that they see every day.
And Olivera is well aware now that the fish-hunting cone
snail, with its intriguing eating habits, is a good place
to start. The snail harpoons fish with a radular tooth, a
hypodermic needle-like structure that injects a paralyzing
venom made up of 100 different components. Once the fish is
harpooned and paralyzed, the snail reels it in and eats it.
By studying the complex neurotoxic venom made by the
snails, Olivera and members of his lab have identified
several drug candidates, as well as gained a better
understanding of how ion channels work. Michael McIntosh,
now a fellow researcher in psychiatry at the University of
Utah, was an undergraduate in Olivera's lab when he
discovered a cone snail toxin whose synthetic form is now
used to treat pain effectively in patients who have become
tolerant to morphine.
Olivera believes that the future of neuroscience depends on
collaboration across disciplines. So he also plans to work
to increase the number of students fluent in neuroscience
by implementing an Interdisciplinary Undergraduate
Neuroscience Program at the University of Utah. Students
whose majors range from math to electrical engineering will
be offered the opportunity to minor in neuroscience. "If we
are to accelerate the pace of scientific progress, we need
people looking at the same problems from different
intellectual viewpoints," he said.
Media Contacts
Cindy Fox Aisen
Howard Hughes Medical Institute
Office phone: 317-843-2276
Email address:
aisenc@hhmi.org
Jennifer Donovan
Howard Hughes Medical Institute
Office phone: 301-843-8859
Email address:
donovan@hhmi.org
Baldomero "Toto" Olivera, Distinguished Professor of Biology
Office phone: 801-581-8370
Email address:
olivera@biology.utah.edu
Lee Siegel, Science News Specialist, University of Utah Public Relations
Office phone: (801) 581-8993
Cell phone: (801) 244-5399
Email address:
leesiegel@ucomm.utah.edu
University of Utah Public Relations
201 Presidents Circle, Room 308
Salt Lake City, Utah 84112
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